UC San Diego bioengineers and material science experts used a nano-bio technology method of placing mesenchymal stem cells on top of very thin titanium oxide nanotubes in order to control the conversion paths, called differentiation, into osteoblasts or bone building cells. Mesenchymal stem cells, which are different from embryonic stem cells, can be extracted and directly supplied from a patient’s own bone marrow.
The researchers described their lab findings in a paper published this week in the Proceedings of the National Academy of Sciences (PNAS), “Stem Cell Fate Dictated Solely by Altered Nanotube Dimension”.
Australian researchers have linked mouthwash containing alcohol to an increased risk of developing oral cancer. The alcohol in mouthwash is believed to allow cancer causing compounds to attack the lining of the mouth more easily.
The review author, Michael McCullough, is an Associate Professor in Oral medicine at Melbourne University. He says dentists need to be aware of the risks of mouthwash. “If they are going to recommend alcohol-containing products then they recommend it for a good reason, for a short period of time,” he said.
“With this evidence that we`ve reviewed, we think it`s not advisable for them to recommend it for the long, over a long period of time.”
Austrian Surgeons have designed a system to produce via CAD/CAM individualized Zirconium Dental Implants for use in case of immediate implant placement. In short, after a tooth is extracted it is scanned and a zirconium copy is milled. The milled copy has macro-retentive features which help secure the new implant in the extraction socket. They report a 90% success rate.
Keystone Dental, funded by private equity firm Warburg Pincus, has settled an unfair competition lawsuit from Noble Biocare for $2million. “The settlement terms provide for Keystone Dental to pay $2 million to Nobel Biocare and that Keystone Dental not hire or solicit any current Nobel Biocare employee through February 1, 2009,” the world`s largest maker of dental implants said in a statement. Nobel Biocare filed a lawsuit in late 2007, saying Keystone Dental systematically targeted and hired Nobel Biocare`s sales and marketing employees to gain an unfair competitive advantage. Under the settlement, Keystone Dental is required to destroy confidential and proprietary information on Nobel Biocare in its or its employees` possession, Nobel said.
Straumann revealed a new implant material, Roxolid [Rock-Solid], a Titanium- Zirconium alloy that is 50% stronger than pure titanium. Initial animal studies show a significant increase in removal torque values over Straumann`s current SLActive titanium implants. Human trials are underway in Europe and North America. Straumann expects to have the design released for initial markets in 2009.
The Wall Street Journal is reporting that Medtronic`s `Infuse Bone Graft` has been linked to life-threatening complications in dozens of patients. The FDA warned surgeons in July that it had received reports of life-threatening complications associated with using the product in surgeries on the cervical spine, around the neck. The agency said it received 38 reports over four years of side effects, mainly swelling of neck and throat tissue, which resulted in compression of the airway and other structures in the neck. Patients reported difficulty swallowing, breathing and speaking. Several required emergency treatment, including tracheotomies and the insertion of feeding tubes, as well as second surgeries, according to reports filed with the FDA.
Dr. Schubert Sapian has designed a innovative root removal system that extracts the entire root without sectioning. A specialized extraction screw is driven into the largest canal then a cushioned silicone fulcrum tray is placed over the adjacent teeth and a pry bar is used to apply vertical pressure to the root resulting in its atraumatic extraction.
Implant pioneer Gerald Niznick`s Implants Direct concept of internet-based factory-direct-to-dentist implant sales plans on launching a copy of the Straumann implant design in September. Having already successfully marketed a copy of Nobel Biocare`s implant designs. Read this interview with an European trade journal for interesting details of the strategy.
The FDA has reinspected the BIORA facility and is satisfied with the improvements made. Because the focus of the observations was on the maintenance of quality system documentation and procedures, changes to Straumann® Emdogain, Straumann® PrefGel and Straumann® BoneCeramic were not needed in order to resolve the FDA issues.
Straumann has changed the delivery mechanism of Straumann® PrefGel from a pipette to a syringe, which will help to ensure easier, more effective handling of the root conditioner.
A court in Germany has dismissed a request from Belgian dental implant software maker Materialise for an injunction against a Nobel Biocare software product, NobelGuide. Belgium software maker, Materialise had alleged the updated version of Nobel Biocare`s NobelGuide software infringed one of its patents, a spokesman for Nobel Biocare told Reuters on Wednesday. The Duesseldorf district court decided that the NobelGuide software does not infringe the Belgian company`s patent. The updated version had been introduced as a response to last year`s decision by the same court that found an infringement in the previous software version, Nobel Biocare said.
Canadian researchers at the NRC Industrial Materials Institute (NRC-IMI) in Boucherville, Quebec have developed a porous titanium foam implant said to mimic a metallic version of bone. The titanium foam is made by mixing titanium powder with a polymer, and then adding foaming agents that expand the polymer when heated. Later, through a high-temperature heat treatment, the polymer is removed and the titanium particles are consolidated to provide mechanical strength to the porous structure. Porous titanium had previously been used in orthopaedic applications, but never for dental implants – although its properties are ideal for this purpose. Louis-Philippe Lefebvre, a powder metallurgy researcher at NRC-IMI, added: `The rough surface creates friction between the implant and the bone, and also allows bone growth into the pores to help fix the implant in place.` Among its potential benefits, titanium foam could make dental implants less invasive. Lefebvre explained that in difficult cases, implantation requires a bone graft. He said: `With better friction, you can insert smaller implants into less bone so patients may not need bone graft surgery.`
Canadian researchers at the University of Alberta have found the surface nanocrystallization of a metallic material is an effective approach for modifying the surface energy of metals. “Our results demonstrate that the combination of surface nanocrystallization and thermal oxidation treatment is a promising approach to suppress the formation of infectious biofilms on metallic materials, thus providing a surface technique to minimize bacterial biofilms on implant surfaces for improved orthodontic and orthopedic applications” says Li the lead researcher. This surface modification is promising not only for suppressing bacterial biofilms on medical implant materials but also has potential in treating materials for food processing and storage as well as for bio-corrosion control. Li points out that it is also possible to add additional elements into the nanocrystalline surface layer to further improve surfaces with anti-bacteria capability.
3M ESPE`s digital dental impression system has been selected as a bronze award winner in the International Design Excellence Awards for 2008. This digital dental impression system captures continuous 3D video images to create precise 3D dental models. Intended for use by dentists and hygienists, it eliminates the discomfort of traditional methods and improves communication between patients and dentists by allowing immediate chair-side review. To create a digital impression, the dentist positions the wand in the patient`s mouth and glides the tip over the teeth to capture surface data. The 3D data is collected and reviewed in real-time on the display.
A report by scientists from the Netherlands published in the FASEB Journal identifies a compound in human saliva that greatly speeds wound healing. Scientists found that Histatin, a small protein in saliva previously only believed to kill bacteria was responsible for the healing. Because saliva is a complex liquid with many components, the next step was to identify which component was responsible for wound healing. Using various techniques the researchers split the saliva into its individual components, tested each in their wound model, and finally determined that Histatin was responsible. “This study not only answers the biological question of why animals lick their wounds,” said Gerald Weissmann, MD, Editor-in-Chief of the FASEB Journal, “it also explains why wounds in the mouth, like those of a tooth extraction, heal much faster than comparable wounds of the skin and bone. It also directs us to begin looking at saliva as a source for new drugs
Dr. Jong-Ho Lee, a Korean dentist, has patented his design for a free-angled screwdriver and abutment. The system addresses the prosthetic problem of access screw hole placement. The free-angled driver consists of 2 to 3 sections connected using universal joints which allows the unrestricted rotation of the free-angled driver at any angle. The free-angled driver eliminates the need for a straight channel to access the abutment screw. The abutment screw can be screwed and unscrewed using the curved channel up to 30 degrees and 35Ncm.
Michael Mastromarino, the leader of the body-snatching ring that plundered the corpse of broadcaster Alistair Cooke apologized to the victims as he was sentenced to 18-54 years in prison. “I am deeply sorry for all the emotional pain I have caused to donor families and donor recipients,” he told the Brooklyn Supreme Court in New York. Mastromarino once ran a dental practice on New York`s Fifth Avenue specializing in dental implant surgery. But he was forced to surrender his dental liscence and go into drug rehabilitation after he allegedly abandoned a patient under general anesthetic and was found in his office bathroom with a hypodermic needle in his arm. At a hearing last month, Mastromarino apologized when confronted by angry victims – including a woman who had received stolen bone. Dayna Ryan told the court she was infected with Hepatitis B after receiving an implant of stolen bone in spinal surgery.
“His sick, disgusting, appalling actions, all in the name of greed, have devastated my family,” she said. Two other members of the body-snatching ring had already been sent to jail.
Novel processing of commercially pure titanium (CP Ti) has produced exceptional mechanical properties and recent clinical trials have proven its superior biocompatibility as well. CP Ti is desirable mainly for its superior biocompatibility, but suffers from low strength compared to either steel or alloyed titaniums. Severe plastic deformation (SPD) processing aims to get microstructural refinement to a level not achievable with traditional processing yielding nanocrystalline titanium. Fatigue life has nearly doubled and although damage tolerance suffered, the levels are still more than acceptable for medical devices. Mouse fibroblast cells were seeded to test biological compatibility, and the SPD-processed titanium showed significant improvements in cell occupancy rates, compared to conventionally processed CP Ti. Clinical trials of this material are progressing well using dental implants, where the higher strength has allowed for smaller implants to be fabricated, enabling surgeries that were previously limited by small spaces and insufficient bone to anchor the implant.
Bioengineers and bioscientists at Rice University and Radboud University in Nijmegen, Netherlands, have shown they can grow denser bone tissue by sprinkling stick-like nanoparticles throughout the porous material used to pattern the bone. To grow new bone, tissue engineers typically place bone cells on porous, biodegradable materials called scaffolds, which act as patterns. With the right chemical and physical cues, the cells can be coaxed into producing new bone. As the scaffold degrades, it is replaced by new bone. “Ideally, a scaffold should be highly porous, nontoxic and biodegradable, yet strong enough to bear the structural load of the bone that will eventually replace it,” said lead researcher Antonios Mikos, Rice`s J.W. Cox Professor in Bioengineering, professor of chemical and biomolecular engineering and the director of Rice`s Center for Excellence in Tissue Engineering. “Previous research has shown that carbon nanotubes give added strength to polymer scaffolds, but this is the first study to examine the performance of these materials in an animal model.”
SurgeryTec is a Netherlands based website that allows members to upload and share surgical technique videos and slideshows. The site has a majority of medical surgery related videos, but some oral surgery/implantology related surgeries are also included.
A shortage of NHS dentists is leading to thousands of needless deaths from mouth cancer, according to dental experts. “The survival rate of mouth cancer has not improved in 30 years,” Nigel Carter, chief executive of the British Dental Health Foundation said. “If people were able to gain easier access to a dentist then the 50 per cent mortality rate could be significantly improved. It is Britain`s secret cancer despite killing more people annually than cervical and testicular cancer put together.” There are 4,750 new cases of mouth cancer in Britain a year.
A recent BBC documentary reported that there is an epidemic of poor teeth in Britain. 1 in 5 people never visit the dentist. 1 in 10 is terrified of the dentist chair. Sugar consumption, eating disorders, and bad diet make Britain’s global reputation for being a nation of terrible teeth completely justified.
The Medical College of Georgia School of Dentistry has selected BreakAway, Ltd. to develop a virtual, 3D simulator to help teach students dental implant procedures. The virtual dental office is designed to improve student learning outcomes in the areas of diagnostics, decision making and treatment protocols for enhanced patient therapy outcomes and risk management. The computer application will be initially developed and tested in conjunction with MCG dental students and faculty. It will then be tested by other universities in the NobelBiocare University Partner Program and distributed globally.
3M announced that it will acquire Imtec Corp, a leading manufacturer of mini dental implants. “We are looking forward to the reputation, resources and worldwide reach that 3M brings to help us build this business,” said Ron Bulard, DDS and Chairman of the Board, IMTEC Corp. “Its overall strength in oral care with both the 3M ESPE and 3M Unitek divisions makes them a particularly good partner for us.” This acquisition gives 3M ESPE access to two of the fastest growing segments in the dental industry. “Our combined digital products and expertise will enable a digital ‘total restorative’ approach with more options than ever, including IMTEC implants, 3MTM ESPETM LavaTM crowns, and 3M’s advanced digital workflow solutions,” said Jeffrey Lavers, vice president and general manager, 3M ESPE. “Together, we will have an end-to-end implantology solution, making the process easier, faster and better for dentists everywhere.”
Novalar has developed NV101, a novel compound that is the only local anesthetic reversal agent that accelerates the return to normal sensation and function following restorative and periodontal maintenance procedures. Novalar has contracted with the leading North American supplier of dental anesthesia cartridges to manufacture NV-101. NV-101 treated patients reported the return of sensation and function in less than half the time it normally took after receiving local dental anesthesia. NV-101 induced a 54.8 percent and a 62.3 percent decrease in time to normal for those with anesthesia administered in the mandible and maxilla respectively.
Southern Implants have released an implant design to address immediate placement in maxillary molars. The very wide (8-9mm) diameter tapered implant is designed to obliterate the molar extraction socket. The placement of this implant involves the use of a shaping tap to taper the osteotomy. Their implant design features both an external hex as well as an internal connection.
The Baha system utilizes direct bone conduction, which allows the bone to transfer sound to a functioning cochlea – thereby bypassing the middle ear. This unique hearing treatment is the only system of its kind cleared by the Food and Drug Administration (FDA) to treat hearing loss.
One reason the Baha system works so well is due to its simple design. The Baha system combines a sound processor with an abutment and a small titanium implant. The implant is placed behind the non-functioning ear. Surgery is minor, and Baha recipients report a wide range of advantages over other hearing devices.
The Baha system, which is based on bone conduction, utilizes a titanium implant, which is placed in the skull bone behind the ear. An abutment connects the sound processor with the implant in the bone. This creates direct (percutaneous) bone conduction. In contrast, traditional bone conductors connect indirectly to the bone through unbroken skin (transcutaneous) and work by exerting pressure against the skull.
Direct bone conduction, provided by Baha, gives improved access to sound when compared to traditional bone conductors since sound is not weakened when passing through the skin
Tighter laws are on the cards for dentists wishing to practice implantology in Dubai. A proposed change in policy will require dentists to complete 100 hours of implantology study and to present completed case reports, before being permitted to sit for the oral licensing exam. The move is set to infuriate local product companies, who have previously complained of the United Arab Emirate`s excessive licensing requirements.Industry-led courses are likely to be most affected by the ruling, as most are structured to ensure dentists clock up the 96 hours.
“Most of these courses would not be recognised,” said Dr Elhami Nicolas, of Nicolas & Asp College of Postgraduate Dentistry. “It is a positive change. People were not receiving adequate education.” The news will be a particular blow for Zimmer Dental whose upcoming course, held through Sharjah University`s College of Dentistry, aimed to fast-track local dentists to license level.
Michael Mastromarino, 44, was arrested nearly two years ago, and this month he plead guilty. Mastromarino and two of his associates were charged in 2006 with enterprise corruption, body stealing, opening graves, unlawful dissection and forgery. Authorities released photos of exhumed corpses that were boned below the waist. They said the defendants had made a crude attempt to cover their tracks by sewing PVC pipe back into the bodies in time for open-casket wakes.
The bodies came from funeral homes in New York, Pennsylvania and New Jersey. BTS shipped the bone, skin and tendons to Regeneration Technologies Inc, LifeCell Corp and Tutogen Medical Inc, all publicly traded companies, along with two non-profits, Lost Mountain Tissue Bank and the Blood and Tissue Centre of Central Texas.
Mastromarino plead guilty in March and will be sentenced May 21, to 18 to 54 years in prison.
Researchers at the University of Ankara, Turkey have designed an innovative CAD based implant guide. The design features a plastic stent produced by rapid prototyping methods that snugly fits the implant handpiece and uses a square slot system to guide the drill direction as opposed to the metal/plastic sleeves used by similar systems. This allows for better visualization of the surgical area and negates the use of stepped sleeves of increasing diameter to guide the twist drill. Additionally it eliminates the risk of metal shavings entering the osteotomy site.
A US patent has been issued to Biomet 3i for an implant which features two anti-rotational elements. One anti-rotational feature is adapted to engage a driving tool, while the other anti-rotational feature is adapted to engage an abutment. An implant abutment system is provided with an angled abutment adapted to mate with one of the anti-rotational features. A second, straight abutment is adapted to engage with the other anti-rotational feature. An abutment is provided with resilient fingers to interface with the implant and provide tactile and audible feedback indicating when the abutment is properly seated. An abutment screw extends through the abutment and engages the implant bore distal of the stem of the abutment. The abutment screw limits axial movement of the abutment relative to the implant. A driving tool comprising one of at least retention structure and visual alignment indicia is provided to facilitate screwing the implant into a patient`s bone.
Gendex has released its latest imaging system. The GXB-500 features a medium size form-factor cone beam CT for for implant planning, TMJ analysis, and small oral surgery procedures. The system’s unique Amorphous Silicon Flat Panel sensor yields accurate, highly detailed image quality at the fastest scan and reconstruction rates in the industry (8.9 seconds and 20 seconds respectively), that allow dental teams to experience greatly improved workflow. Adding to the value of the GXCB-500, the system serves a dual function—it also features traditional digital panoramic imaging for capturing 2-D data
Allison, a green sea turtle, lost three of her flippers in a shark attack. To prevent her swimming in a permanent spiral, researchers plan on fitting a prosthetic flipper attached via a dental implant. The other option would be an external strap-on device. She was rescued in 2005 on the sub-tropical shores of South Padre Island on the Texas Gulf coast and now resides in a small tank at Sea Turtle, Inc, a research and conservation center which among other things rehabilitates injured sea turtles. The implant will go where her lower left flipper once was and even if it is successful she will still not be released back into the wild as the flipper will have to be replaced periodically and enlarged as she grows. The dental implant will be the work of Dr. Sudarat Kiat-Amnuay, an assistant professor at The University of Texas Dental Branch at Houston. It might work on Allison because the size of the dental implant ranges from 2 mm to 6 mm and the diameter of her bone is about 10 mm. “We are going to drill into the bone and then place the implant and let it integrate for a few months and if it integrates then we can add the flipper,” she said. The prosthetic appendage would be made from an imprint of a flipper of a dead turtle of a similar size.
Researchers at the Dunedin School of Medicine, Dunedin, New Zealand have reported in the Journal of the American Medical Association (JAMA) that Cannabis smoking may be a risk factor for periodontal disease that is independent of the use of tobacco. Tobacco smoking was strongly associated with periodontal disease experience, but there was no interaction between cannabis use and tobacco smoking in predicting the condition`s occurrence
Biomet 3i have developed a protocol and set of surgical instruments for use with their implants in CT guided surgery. The Navigator System utilizes a surgical plan devised from CT images using Materialises`s Simplant Technology and a combination of specially designed surgical and laboratory drills and instruments to allow template-based implant positioning and immediate restoration if so desired.
ZikonZahn have developed the Zirkograph, a copy-milling unit, that is a manually operated machine for the manufacture of crown & bridge frameworks. An analog model is scanned using a stylus and enlarged by the panthographic principle when milling frameworks out of zirconia blanks. The Zirkograph 025 ECO can mill single abutments to 14 unit bridges or occlusal screwed bridges.
Denture cleaners like Polident and Fixodent have caused serious and sometimes fatal reactions in some people. The Food and Drug Administration (FDA) announced Monday that one person died and at least 72 others were sickened as a result of allergic reactions to denture cleaners. In some cases, the reactions were a result of product misuse. The FDA report blamed a bleach called persulfate, an allergen used in most denture cleansers. Persulfates are used in these products as part of the cleaning and bleaching process. The FDA is urging doctors and patients to be aware of the symptoms of an allergic reaction and to only use the cleansers as directed. The person who died and some of those who were sickened misused the cleaners, the FDA said. “Some patients have gargled or swallowed it, resulting in abdominal pain, vomiting, seizure, hypotension and difficulty breathing,” it said. Meanwhile, some who reported allergic reactions used the cleaners properly, the FDA said.
Dr Christopher Lie of the Sussex Eye Hospital in Brighton, England performed a sight restoring procedure called Osteo Odonto Kerato Prosthesis (OOKP) which involves fitting a living canine tooth with an optical cylinder and transplanting it into the eye cavity, restoring a blind Irishman`s sight. The procedure involves removing a canine tooth, a part of the adjacent bone and related ligaments from a patient. It is attached in the first stage to the cheek area to develop a blood supply and is allowed to heal for several months.
Later the tooth complex is removed from the cheek area and placed within the eye, attaching a corneal replacement implant. Bob McNichol, 57, from County Mayo in the western part of Ireland was blinded by a freak accident explosion involving melted aluminum at a recycling business two years ago received the tooth from his son Robert, 23.
Swiss company Nobel Biocare bought Israeli dental implant startup Alpha Bio for $95 million. Alpha Bio Implant was a one-man show: Dr. Ophir Fromovich, CEO, owner and dentist to the stars, not that he`ll say who his clients are. Fromovich founded Alpha Bio Implant in 1988. Alpha Bio created a new type of implant, the first generation of what became called the NobelActive, the implant with the novel thread pattern. The device Web site explains that it does not “cut through bone like conventional implants,” it presses through it like a corkscrew. Patients with old-type implants had to wait three to six months for the traumatized jawbone to stabilize before the crown could be “loaded”. Also, these old implants could cause bone erosion and lead the gums to recede, which is unsightly. The new one does none of that, says Fromovich. It even suits “soft bone” situations, and causes very little injury to the bone tissue. Also, in most cases, the crown can be loaded on immediately, which is the ultimate victory for the inventors: No need to wait for months to see the patient`s white smile.
Swiss Researchers at the Paul Scherrer Institute have developed a novel method for producing dark-field x-ray images at wavelengths used in typical medical and industrial imaging equipment. Dark-field images provide more detail than ordinary x-ray radiographs and could be used to diagnose the onset of osteoporosis, breast cancer or Alzheimer’s disease. Unlike traditional x-ray images, which show a simple absorption contrast, dark-field images capture the scattering of the radiation within the material itself, exposing subtle inner changes in bone, soft tissue, or alloys. The overall clarity of the images is striking. The improved sensitivity in measuring bone density and hairline fractures could help diagnose the onset of osteoporosis.
BlueSkyBio have released their design of a Nobel Replace Clone. It features an ActivFluor surface treatment for enhanced osseointegration and is compatible with NobelReplace drills, prosthetics and laboratory components. Their design also features increased fracture resistance at over 100Ncm and enhanced apical threads for greater primary stability. Their implants are about 1/3 of the price of Nobel`s Replace and include a cover screw and 3mm healing abutment.
Researchers at the Regea Institute of Regenerative Medicine, part of the University of Tampere, Finland have successfully replaced a 65-year-old patient`s upper jaw with a bone transplant cultivated from stem cells isolated from his own fatty tissue and grown inside his abdomen. Stem cells were isolated from the patient`s fat and grew for two weeks in a specially formulated nutritious soup that included the patient`s own blood serum. When they had enough cells to work with, they attached them to a scaffold made out of a calcium phosphate biomaterial and then put it inside the patient`s abdomen to grow for nine months. The cells turned into a variety of tissues and even produced blood vessels, the researchers said. The block was later transplanted into the patient`s head and connected to the skull bone using screws and microsurgery to connect arteries and veins to the vessels of the neck. The patient`s upper jaw had previously been removed due to a benign tumor and he was unable to eat or speak without the use of a removable prosthesis.
Aspiring Mexican dentists are moving to border cities in droves and are luring American patients away from farther flung discount destinations such as Hungary and Thailand. A dental crown in the United States costs upward of $600 per tooth, compared to $190 or less in Mexico. Americans have long crossed the border for cheap medicines, flu vaccines, eye surgery or specialist doctors, but dentists are now in highest demand. “We`ve gone from a handful of patients when we started 2-1/2 years ago to 150 new patients a month,” said Joe Andel, an American who owns the Rio Dental clinic in Ciudad Juarez with his Mexican dentist wife, Jessica. Rio Dental, which uses U.S. labs to make its crowns, picks patients up at the airport in El Paso, Texas, across the border and has treated people from as far away as Alaska and Hawaii. “The Internet makes this possible. It allows patients to find us and research us and shows we can do dental work of equal or superior quality to the United States,” Andel said.
Internet bloggers swap stories and compare notes about Mexican dentists, but it always comes down to money.
Three years after patients were given Nobel Direct dental implants, the risk of the implant loosening has increased even more. A follow-up by researchers at the Sahlgrenska Academy shows that eight per cent of the implants are lost. “We have followed up 48 patients who were among the first to get the implant. For each passing year, we have been able to see how the problems related to these implants have grown more and more,” observes Pär-Olov Östman, a dentist who will be presented the study tomorrow at the defense of his dissertation.
After one year, about five per cent of the implants had been lost, and 20 per cent of the remaining implants showed bone loss of more than three millimeters. The new report indicates that after three years, eight per cent of the implants had been lost, and 25 per cent of the remaining implants showed bone loss of more than three millimeters. “We believe that the problems related to Nobel Direct result both from the design of the implant and an uneven surface against the soft tissue in combination with the method of treatment recommended by the company,” according to Professor Lars Sennerby.
Researchers at The University of Texas Health Science Center at Houston can identify and quantify specific protein markers in human saliva to provide an early, non-invasive diagnosis of breast cancer, according to a study published in today’s issue of the journal Cancer Investigation. “Why not the dentist?” said lead researcher Charles Streckfus, D.D.S., . “Most folks, especially women and children, visit the dental office way more often than they ever see the physician. Saliva is a non-invasive, quicker way for detection.” Streckfus and his team compared the levels of expression of proteins in the saliva of patients with either malignant or benign tumors to saliva from normal controls to find those that are abnormally expressed in the diseased state. Patients’ proteins that are significantly higher or lower than the norm were considered biomarker candidates. Streckfus and his collaborators are continuing to pursue salivary diagnostics for other types of cancer, such as ovarian, endometrial, cervical and head and neck cancers.
ImplantVision have added to their implant-centered patient education system `PatientVu` by releasing it in 12 languages. The available languages are: Spanish, Italian, German, French, Portuguese, Mandarin, Cantonese, Korean, Japanese, Arabic, Russian and Polish.
Researchers at the Chemistry and Biochemistry Department at National Chung Cheng University in Taiwan has published a paper in Nanotechnology demonstrating the use of gold nanoparticles in occluding dental tubules. Researchers have found that sensitive teeth have an increased number of dentinal tubules (35.6% compared to 9.3%) and are wider in diameter (0.83 µm compared to 0.43 µm) than the dentinal tubules of non sensitive dentine. The Chinese researchers have demonstrated that this tubules can be blocked with the aid of gold nanoparticles.
An interesting aspect of gold at the nanoscale is that gold nanoparticles exhibit a clear size-dependent trend: the smaller gold nanoparticles get, the lower is their melting point. This deviation of the melting temperature from the bulk value becomes dramatic at a size around 5 nm in diameter, ultimately reaching well under 50% of the bulk melting point of gold.One of the methods of closing sub-micron sized dentinal tubules explored by Dr. Chris Wang and his team involved the sintering of highly concentrated gold nanoparticles that were brushed into the exposed open ends of dentinal tubules. Laser irradiation induced the photofusion of gold nanoparticles via photothermal conversion.
Creative Marketing and Merchandising Media Solutions (c3ms), a provider of digital signage networks, recently announced the launch of the NobelVision Network throughout North America. The NobelVision Network is a customized channel of dental healthcare information specifically designed to educate the patients of Nobel Biocare`s customers on their dental options by delivering quality educational, informational and entertainment segments via an IP-based, networked narrowcast system. Presented on large flat-panel screens installed in dental offices, the NobelVision Network provides a unique opportunity for advertisers and content partners to market their products and services to a targeted, health conscious audience with known demographic and statistical data.
With the growing population of patients who actively research their own healthcare options, having fresh, up-to-the minute information that`s pertinent to their needs makes the wait in the dentist`s office a more productive experience,” said Kevin Mosher, Vice President & General Manager, Nobel Biocare North America. “For dentists, it`s always better to have educated patients, particularly when they become knowledgeable about additional services that may be of benefit to them. The NobelVision Network represents a strategic vehicle to deliver timely and relevant information in an appropriate setting for the benefit of both parties.” Implementation of this private promotional and advertising network is currently underway and will be installed in 200 dental offices using Nobel Biocare products by the end of 2007
JDentalcare have released a one-piece implant designed for immediate function. The aggressive threading features a very deep coil depth designed to provide increased primary stability even in soft bone. Additionally each thread features a series of little steps on the inside of the thread. These steps increase the bone to implant contact area by 15%. The available implant diameters range from 3-5mm and range in length from 10 to 18mm.
Regeneration technologies have started to manufacture bone screws from bovine metatarsals. These are used in reconstructive surgery such as repairing the torn anterior cruciate ligament that plagues many athletes. The bone is obtained from specially bread cows at the Pranther Ranch. Prather Ranch “allows us the opportunity to satisfy many concerns about sourcing bovine materials because of the way they do their business,” said Carrie Hartill, chief scientific officer at Regeneration. “They are the largest closed herd and safeguarded with proper health and animal husbandry.”
In addition to the special precautions Rickert takes in breeding his cattle, the cow bones need special preparation before they can be used in human surgery. Regeneration and other companies use cleaning techniques (Regeneration`s proprietary version is called BioCleanse) to ensure that no living material remains on the bone. That cuts down on the risk of disease transmission and prevents antigenicity, which happens when the body`s immune system attacks a foreign substance.With clean bones, the work of turning bone into bone screw can begin. “The first thing we do is shape into rough-hewn shapes around the size and specification you might need,” Hartill said. “Then you do the fine machining. It`s actually a screw and it has a thread, so we use identical (cutting and milling) equipment to the titanium-screw manufacturers.”
The selling point for using bovine biological materials is that the body responds to it as it would human tissue, absorbing it into the body.
“It eventually remodels into the host bone from six to 12 months” after surgery, Hartill said. “We have instances where surgeons have had to go in to do a repeat surgery and they haven`t been able to find the bovine bone anymore.”
Drs. Marx et al. of the University of Miami have published a comprehensive paper on `Risk factors, Prediction of Risk using Serum CTX Testing, Prevention and Treatment` of Oral Bisphosphonate-Induced Osteonecrosis in the December 2007 issue of the Journal of Oral Maxillofacial Surgery (pages 2397-2410). It gives specific guidelines to help to assess the risk of BRONJ and a suggested course of treatment should the condition develop in one of your patients.