Category Archives: Bone Grafting

Densah Burs – OsseoDensification Bur Kit

Versah, a company started by Michigan Periodontist, Dr. Salah Huwais , have designed a
set of multi-fluted osseodensification burs for implant placement. Osseodensification is a novel, biomechanical, non-excavation  preparation method that compacts and autografts bone during the osteotomy. The burs will remove bone when spun clockwise, however when spun counterclockwise they collect and compact bone chips into the osteotomy wall and result in greater local bone density and higher insertion torques. They can also be
used for internal sinus lifts and ridge expansion.

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Topic: Bone Grafting, Drill Design, Instrument Design, Patent, Sinus Lift

MIT NanoTech Team produces a SuperGlue for Implants

An Massachusetts Institute of Technology (MIT) research team that may have found a way to make bone implants less likely to fail using a high-tech adhesive that more securely bonds implants to bone by promoting cell growth between natural and artificial body parts.

In a study published in the June 26 online edition of Science Translational Medicine, the MIT team and its collaborators from several other institutions reported that the implant adhesive — a multilayered coating of ceramic and nanolayers of polymers infused with proteins — worked so well on lab rats that they will soon be ready to test it in humans.

The nanolayers, or super-thin sheets of material, hold therapies such as growth factors

Professor Paula Hammond specializes in materials design and molecule delivery at very small scales

that attract and encourage the formation of bone cells, causing them to firmly attach to the titanium implant. The coated implants required significantly more force to pull free than uncoated ones; indeed, the researchers said the resulting bond is so strong that under stress, the bone would fracture first before the interface with the implant.

The implant coating works like a tiny, elegant machine. The top coating consists of repeating layers, each impossibly thin, that contain the bone growth factor BMP-2. The layers gradually break apart over a period of weeks, releasing BMP-2 into the body. The factor then stimulates stem cells in bone marrow to transform themselves into new bone cells.

The bottom part of the coating is made of a ceramic that mimics bone, thereby attracting bone cells to its surface. This side of the coating is attached to the implant, and recently formed bone cells tend to affix to this ceramic and grow outward, adhering like “superglue” to attach the implant to the bone.

Read more at the Boston Globe

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Topic: Biologics, Bone Grafting, Research Tagged , |

Harvard / Yale Study examines increased cost Of Medtronics`s Infuse Bone Growth Protein use

The use in spine surgery of bone-growth proteins like Medtronic Inc.’s product Infuse has led to widespread nationwide increases in hospital charges ranging from 11% to 41% above conventional surgical costs, researchers found.

The researchers studied the results of a broad U.S. sample of 328,000 spine surgeries from 2002 through 2006. They report their findings this week in JAMA, the Journal of the American Medical Association.

The authors, from both Brigham & Women’s Hospital in Boston and from Yale, also found that by 2006 the use of the new bone proteins, especially Infuse, had increased to nearly 25% of all operations in which spinal vertebrae are fused together to alleviate back pain.

“People know bone-growth protein is expensive, but this gives an idea of how expensive,” said Kevin S. Cahill, the lead author and a neurosurgeon at Brigham & Women’s hospital.

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Topic: Bone Grafting

Cerapedics Develops Peptide Coated Bone Grafting Material

Cerapedic`s i-FACTOR bone graft is the only biologic bone graft that combines a unique anorganic bone mineral (ABM) and small peptide (P-15™) to act as an attachment factor for specific integrins on osteogenic cells. This novel mechanism of action enhances the body’s natural bone healing process resulting in safe, predictable bone formation at a lower cost than growth factors. ABM/P-15 has been in human clinical use for more than thirteen years in an estimated 500,000 patients worldwide. P-15 is a synthetic fifteen amino acid peptide that mimics the cell-binding domain of Type I human collagen and is responsible for osteogenic cell attachment to Type 1 human collagen.

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Topic: Bone Grafting

Laser Melting produces Custom Fit Bone Replacement Graft

The body can heal minor bone injuries itself – but with major injuries, it needs help. Researchers at the Fraunhofer Institute for Laser Technology have developed a process called Selective Laser Melting (SLM) by which a razor-thin laser beam melts pulverized material layer-by-layer to produce structures that may be as delicate as 80 to 100 micrometers. The porous canals create a lattice structure which the adjacent bones can grow into. Its basic structure consists of the synthetic polylactide, or PLA for short. Stored granules from tricalcium phosphate (TCP) ensure rigidity and stimulate the bone‘s natural healing process. As pastes, granulates and semi-finished products, TCP and PLA already have proven to be degradable implants. The body can catabolize both substances as rapidly as the natural bones can regrow. But the material can only be applied in places where it will not be subject to severe stress: Thus, the »Resobone« implants will primarily replace missing facial, maxillary and cranial bones

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Topic: Bone Grafting

Osteo-Alchemy: Turning Wood into Bone

Anna Tampieri at the Institute of Science and Technology for Ceramics, Faenza, and colleagues have turned wood into bone mimics that could be used to repair damaged limbs. The Italian scientists were inspired by nature`s highly organised hierarchial structures to make porous hydroxyapatite scaffolds with structures similar to that of real bone. The scaffolds `pave the way for realising prosthetic devices which could get closer to the extraordinary performance of human tissues`, they claim.
The team heated the wood to decompose the organic parts that make up most of its weight, leaving behind the carbon template. They reacted the template first with calcium, then oxygen and then carbon dioxide to form calcium carbonate. Finally, they converted it to hydroxyapatite using a phosphate donor. The material keeps its original microstructure, exploiting the unique architectural properties of the wood`s cellular make-up, explains Tampieri. This means cells and blood vessels can grow through the structure and incorporate it into the original bone.

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Topic: Bone Grafting

Infuse Bone Graft Study Faked by US Army Surgeon

A former US Army orthropedic surgeon, Dr. Timothy Kuklo, previously accused of falsifying a study on a bone growth product used on severely injured Iraq war veterans has resigned his teaching position at Washington University in St. Louis. He was placed on leave earlier this year while the university investigated charges against him. Medtronic, a maker of the bone growth product Infuse, also suspended his consulting contract. The company paid him nearly $800,000 the last few years. An investigation last year by Walter Reed Army Medical Center in Washington, where Dr. Kuklo worked before joining the university, concluded that he had falsified parts of a study that claimed greater benefits than other Army surgeons reported for the Medtronic bone growth product. The Army reported its findings to the university and a medical journal. Dr. Kuklo was also found to have forged the signatures of four listed co-authors, who told Army investigators that they did not approve the study. The British Journal of Bone and Joint Surgery retracted the study earlier this year

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Topic: Bone Grafting

JDental Care releases JDMultiscraper Bone Harvester

The JDMultiscraper is designed for autologous bone harvesting. It features a autoclavable body with interchangeable blades, which can be changed once cutting performance degrades.

Topic: Bone Grafting

NY Oral Surgeon gets 18-54 yrs in Jail for Bodysnatching

Michael Mastromarino, the leader of the body-snatching ring that plundered the corpse of broadcaster Alistair Cooke apologized to the victims as he was sentenced to 18-54 years in prison. “I am deeply sorry for all the emotional pain I have caused to donor families and donor recipients,” he told the Brooklyn Supreme Court in New York. Mastromarino once ran a dental practice on New York`s Fifth Avenue specializing in dental implant surgery. But he was forced to surrender his dental liscence and go into drug rehabilitation after he allegedly abandoned a patient under general anesthetic and was found in his office bathroom with a hypodermic needle in his arm. At a hearing last month, Mastromarino apologized when confronted by angry victims – including a woman who had received stolen bone. Dayna Ryan told the court she was infected with Hepatitis B after receiving an implant of stolen bone in spinal surgery.
“His sick, disgusting, appalling actions, all in the name of greed, have devastated my family,” she said. Two other members of the body-snatching ring had already been sent to jail.

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Topic: Bone Grafting

Oral Surgeon pleads guilty in NY Bone Snatching Case

Michael Mastromarino, 44, was arrested nearly two years ago, and this month he plead guilty. Mastromarino and two of his associates were charged in 2006 with enterprise corruption, body stealing, opening graves, unlawful dissection and forgery. Authorities released photos of exhumed corpses that were boned below the waist. They said the defendants had made a crude attempt to cover their tracks by sewing PVC pipe back into the bodies in time for open-casket wakes.
The bodies came from funeral homes in New York, Pennsylvania and New Jersey. BTS shipped the bone, skin and tendons to Regeneration Technologies Inc, LifeCell Corp and Tutogen Medical Inc, all publicly traded companies, along with two non-profits, Lost Mountain Tissue Bank and the Blood and Tissue Centre of Central Texas.
Mastromarino plead guilty in March and will be sentenced May 21, to 18 to 54 years in prison.

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Topic: Bone Grafting

K System from Dentak

Dentak have released an innovative combination trephine/bonemill/delivery system for harvesting and delivering autogenous bone. The trephines which come in a variety of sizes from 3.2mm to 6.2mm feature a drill blade inside the trephine which mills the bone as it is removed by the trephine. The whole trephine is then placed in a handle for delivery to the recipient site.

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Topic: Bone Grafting

Inkjet Printers Produce Custom Bone Grafts

Tissue Engineering Researchers at the University of Tokyo Hospital and venture company Next 21 are using 3D inkjet printers to produce tailor-made artificial bones for use in facial reconstructive surgery. To make an artificial bone with this technology, a 3D computer model of the bone is first created based on the patient’s X-ray and CT scan data. The computer model is then sliced into a large number of cross-sections and the data is sent to a special 3D inkjet printer, which works like an ordinary inkjet printer by transferring tiny droplets of liquid onto a surface. However, unlike ordinary printers that print on paper, this one prints onto thin layers of powdered alpha-tricalcium phosphate (alpha-TCP). The “ink” is a water-based polymer adhesive that hardens the alpha-TCP it comes into contact with. By repeatedly laying down the powder and printing successive layers on top of one another, the printer is able to physically reproduce the desired bone to an accuracy of one millimeter

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Topic: Bone Grafting

Socket Repair Membrane

Zimmer`s Socket Repair Membrane is a specially shaped collagen membrane designed to assist wound healing in alveolar facial plate repair and residual ridge preservation following atraumatic, flapless single-root tooth extractions. It is pre-cut to fit single root sockets, saving the clinician time and limiting waste. The membrane contains graft material by capping the socket with the circular portion of the membrane and helps retain the post extraction buccal wall preventing the bone particles from dispersing into the tissue and preventing the migration of the epithelial cells into the site. Developed in conjunction with Dr. Dennis Tarnow at NYU to help maximize long term esthetic results and function.

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Topic: Bone Grafting