Category Archives: Implant Surface

Electrochemical HA Coating Process Yields Stronger Bond to Implants

Tel Aviv University researcher Prof. Noam Eliaz of the TAU School of Mechanical Engineering has developed an electrochemical process for coating metal implants which vastly improves their functionality, longevity and integration into the body. “The surface chemistry, structure and morphology of our new coatings resemble biological material,” explains Prof. Eliaz. “We`ve been able to enhance the integration of the coating with the mineralized tissue of the body, allowing more peoples` bodies to accept implants.” His new coating resulted in a 33% decrease in the level of materials failure, or delamination, in these implants.
The next-generation coating will include nano-particles to reinforce the coating. It will also have the potential to incorporate biological material or drugs during the process itself.

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Topic: Implant Surface

Intelligent Metal Surfaces direct Osteoblast Cell Activity and Fate

Université de Montréal Researchers have modified metal surfaces such as titanium producing a sponge-like pattern of nano pits that increased growth of bone cells, decreased growth of unwanted cells and stimulated stem cells, relative to untreated smooth ones. In addition, expression of genes required for cell adhesion and growth were increased in contact with the nanoporous surfaces. “We demonstrated that some cells stick better to these surfaces than they do to the traditional smooth ones,” says Dr. Nanci. “This is already an improvement to the standard available biomaterial.” “Using chemical modification, we have produced metals with intelligent surfaces that positively interact with cells and help control the biological healing response. These will be the building-blocks of new and improved metal implants that are expected to significantly affect the success of orthopedic, dental and cardiovascular prostheses.”

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Topic: Implant Surface

Nanotubes and Stem Cells Accelerate Bone Growth

UC San Diego bioengineers and material science experts used a nano-bio technology method of placing mesenchymal stem cells on top of very thin titanium oxide nanotubes in order to control the conversion paths, called differentiation, into osteoblasts or bone building cells. Mesenchymal stem cells, which are different from embryonic stem cells, can be extracted and directly supplied from a patient’s own bone marrow.

The researchers described their lab findings in a paper published this week in the Proceedings of the National Academy of Sciences (PNAS), “Stem Cell Fate Dictated Solely by Altered Nanotube Dimension”.

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Topic: Implant Surface

Titanium Foam – New Implant Surface

Canadian researchers at the NRC Industrial Materials Institute (NRC-IMI) in Boucherville, Quebec have developed a porous titanium foam implant said to mimic a metallic version of bone. The titanium foam is made by mixing titanium powder with a polymer, and then adding foaming agents that expand the polymer when heated. Later, through a high-temperature heat treatment, the polymer is removed and the titanium particles are consolidated to provide mechanical strength to the porous structure. Porous titanium had previously been used in orthopaedic applications, but never for dental implants – although its properties are ideal for this purpose. Louis-Philippe Lefebvre, a powder metallurgy researcher at NRC-IMI, added: `The rough surface creates friction between the implant and the bone, and also allows bone growth into the pores to help fix the implant in place.` Among its potential benefits, titanium foam could make dental implants less invasive. Lefebvre explained that in difficult cases, implantation requires a bone graft. He said: `With better friction, you can insert smaller implants into less bone so patients may not need bone graft surgery.`

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Topic: Implant Surface

Straumann to test Mussel-Based Implant Adhesive Coating

Over the course of evolution mussels have developed a special glue that not only works under water, but is also a particularly firm and lasting bonding agent. The strength of the bond is due to a particular protein.
Dr. Klaus Rischka, a chemist at the Fraunhofer Institute for Manufacturing Engineering and Applied Materials Research IFAM in Bremen and his partners at Frankfurt University Hospital, the Center of Biotechnical Engineering BitZ at Darmstadt University of Technology, the State Materials Testing Institute MPA and the implant manufacturer Straumann in Freiburg will initially demonstrate the glue`s suitability on the basis of a dental implant made of titanium.
It is current practice to anchor tooth implants in the jaw bone without an adhesive. This often leaves gaps between the gums and the metal, allowing bacteria to enter and cause infections. A glue that firmly connects the gums to the implant would serve as an effective barrier against aggressive germs.
Conventional products are not suited to such a purpose, however, as they would sooner or later dissolve in the moist environment inside the mouth.
The use of this substance in medical applications requires an additional ingredient: a growth protein, which can likewise be synthetically produced using the classic technique of solid-phase peptide synthesis. Its purpose is to stimulate cell growth so that the body`s own tissue -in this case the gums – bonds as closely as possible with the implant.

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Topic: Implant Surface

Friadent Plus – Next Generation Surface from Dentsply Friadent

Dentsply Friadent had released their next generation implant surface which features a thermal etching process called BioPoreStructuring. They claim the specific etching acid they use creates an ideal physical, chemical and biological surface needed to attract osteoblasts to the implant surface.

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Topic: Implant Surface

NanoTite – HA splutter coated titanium surface

Bicon have developed a new surface process, NanoTite™. A high-energy ion beam source aims a beam of ions at the surface of a target treated with HA. These high-energy ions eject the HA from the target/substrate and create a molecular cloud whose molecules bond with the surface of the Bicon Ti 6Al-4V ELI implant. This Ion-Beam Assisted Deposition process, which provides increased integration with the implant surface, is known as High-Energy Sputter Deposition. Using an Ion-Beam Assisted Deposition process, the titanium alloy is modified with a thin (less than 1 micrometer) amorphous calcium phosphate compound with HA-like chemistry and physical properties for enhancement of bone integration.

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Topic: Implant Surface

rhBMP-2 Bone Regeneration Around Implants

Ulf Wikesjö of the Medical College of Georgia has demonstrated impressive osseous regeneration around dental implants coated with recombinant human Bone Morphogenic Protein (rhBMP-2). Dr. Wikesjö is researching wound-healing and tissue regeneration with a $1.4 million grant from Nobel Biocare. In laboratory tests, rhBMP-2 applied onto implants directs endogenous stem cells to become bone-forming cells. The result was a nearly complete regeneration of lost tissue. He hopes to start clinical trials in the summer of 2006.

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Topic: Implant Surface

Anti-Microbial Implant NanoSurface

Brown University engineers have shown that both zinc and titanium oxide nanosurfaces can reduce the presence of bacteria. Discs with nanostructured surfaces had bumps that measured only .023 microns in diameter. Discs with microstructured surfaces had bumps that measured about 5 microns in diameter. Microstructured zinc oxide discs were host to 1,000 times more bacteria than the nanostructured zinc oxide discs. Similar, but less striking, results were duplicated on titanium oxide discs. The engineer`s hypothesis is that: `with the nanostructured surfaces we created, surface area increased by 25 to 35 percent. We think that this additional area, along with the unique surface energetics of these nanomaterials, gave bone-forming cells more places to adhere. But with bacteria, increased surface area may work the other way, exposing the bugs to more of the germ-fighting properties of the zinc oxide.`

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Topic: Implant Surface

BioFunctional Implant Coating – US Patent Issued

Straumann has received a US patent for a bioactive coating for their implants. Their modified sandblasted and acid-etched (SLA) surface is coated with an
Arg–Gly–Asp (RGD)-peptide-modified polymer (PLL-g-PEG/PEG–RGD). According to a study by Danny Buser, RGD-coated implants demonstrated significantly higher percentages of bone-to-implant contact as compared with controls at 2 weeks. The hypothesized mechanism is that the attachment of RGD peptides directed towards integrin receptors on the PEGylated surface promotes adhesion of cells of mesenchymal origin e.g. osteoblasts to the implant surface.

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Topic: Implant Surface

ZiUnite ™ – Nobel`s new Zirconium Implant Surface?

Nobel Biocare makes mention of their new all-ceramic implant design that uses a zirconium based surface in their annual report (page 35). Clinical trials are in progress. It seems interest in Zirconium Oxide based implants is on the rise by the big companies. Definitely a trend to keep an eye on.

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Topic: Implant Surface

Nobel Biocare`s Groovy Implant Surface

Nobel Biocare has introduced an improvement to their Ti-Unite Surface. By placing micro grooves on the surface they claim to increase the implant stability by up to 30% thereby allowing for more rapid bone formation. This surface improvement takes a mechanical approach to increase Bone-to-Implant Contact as opposed to the chemical surface modification`s introduced by Astra (Osseospeed) and Straumann (SLAtive), their main competitors.

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Topic: Implant Surface

SLActive – New Hydrophilic Implant Surface Treatment

Straumann has introduced an improvement in their SLA implant surface. SLActive is based on the scientifically proven SLA® surface topography, but exhibits a fundamentally improved surface chemistry. Due to its ideal conditioning, the chemically active and hydrophilic SLActive surface significantly promotes the osseointegration process. Animal studies demonstrate that their new surface allows for accelerated bone remodelling during the entire osseointegration process.

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Topic: Implant Surface