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No Cement, No Screws , Yes Memory Metal Retention – RodoMedical

To cement or to screw – that is the question. Not anymore, startup RODO Medical has added a new option. Reversible retention using a shape memory metal dental retention system which uses one or more compression plates made from various shape memory materials, e.g., nickel-titanium alloys such as Nitinol. By applying energy via heat or electrical energy, the memory metal elements change shape. To remove a crown, energy is applied via a wand and the memory metal retentive element shape

MIT NanoTech Team produces a Super Glue for Implants

An Massachusetts Institute of Technology (MIT) research team that may have found a way to make bone implants less likely to fail using a high-tech adhesive that more securely bonds implants to bone by promoting cell growth between natural and artificial body parts. In a study published in the June 26 online edition of Science Translational Medicine, the MIT team and its collaborators from several other institutions reported that the implant adhesive — a multilayered coating of ceramic and nanolayers

Metallic Glass developed for Dental Implants

Researchers at the California Institute of Technology have developed a Palladium based glass that is an alloy of the noble metal palladium, a small fraction of silver, and a mixture of other metalloids—has shown itself in tests to have a combination of strength and toughness at a level that has not previously been seen in any other material. “Our study demonstrates for the first time that this class of materials, the metallic glasses, has the capacity to become the toughest

Tooth Regeneration Gel

A new peptide, embedded in a soft gel or a thin, flexible film and placed next to a cavity, encourages cells inside teeth to regenerate in about a month, according to a new study in the journal ACS Nano. This technology is the first of its kind. The new gel or thin film could eliminate the need to fill painful cavities or drill deep into the root canal of an infected tooth. The gel or thin film contains a peptide

Titanium Foam developed for Dental Implants

Scientists at North Carolina State University have developed a new lightweight “metal foam” with elasticity similar to bone that could lead to a new generation of medical implants, likely overcoming a range of problems associated with devices currently in widespread use. “Our composite foam can be a perfect implant material to prevent stress shielding,” said Rabiei, the lead researcher. “This is because the modulus of our composite foam is matching perfectly with that of bone. That means when the implant

Why Oral Pain is Difficult to Locate Accurately

To see how the brain responds to pain emanating from different teeth, researchers led by Clemens Forster of the University of Erlangen-Nuremberg in Germany used fMRI to monitor changes in activity when the upper tooth or the lower tooth was zapped. “At the beginning, we expected a good difference, but that was not the case,” Forster says. Because the same regions were active in both toothaches, the brain — and the person — couldn’t tell where the pain was coming

Brookhaven Lab and BioSET, Inc., Patent a Synthetic Peptide That Enhances Bone Growth

Brookhaven Science Associates, the company that operates and manages the U.S. Department of Energy’s Brookhaven National Laboratory (BNL), and Biosurface Engineering Technologies, Inc. (BioSET), have been issued a U.S. patent on a synthetic peptide, called B2A. B2A enhances the effects of a tissue growth factor known as bone morphogenetic protein 2, or BMP-2. BMPs are a family of proteins in the human body responsible for the proliferation, repair and differentiation of cells in many tissues, including bone. Tom Rouche, BioSET

All you ever wanted to know about Titanium

This interesting article about `Titanium uses in Industry` reveals some facts you may not have known about your favorite metal: It has an extremely low response to magnetism Its use in medicine also encompasses surgical instruments and those used in image-guided surgery and magnetic resonance imagery. It is the ninth most plentiful element present in the Earths crust. It has been found in meteorites and detected in the sun and class M stars. The Apollo 17 moon mission brought back

Transcription Factor found that Controls Ameloblast Function (Enamel Production)

Scientists at Oregon State University have found a gene involved in enamel production. In the latest research, published in Proceedings of the National Academy of Sciences, a team led by Chrissa Kioussi and Mark Leid bred mice that lacked a gene known as Ctip2. The gene, called Ctip2, is a “transcription factor” that was already known to have several functions – in immune response, and the development of skin and the nervous system. Scientists can now add tooth development to

AAE: Dental Implants Require Much More Follow-up Treatment than Root Canals

A study in the November issue of the Journal of Endodontics claims that dental implants require much more follow-up treatment than root canals, according to a study by researchers at the University of Alabama at Birmingham. Their study results reported that the success rate for the dental implants was 98.4 percent; for root canals it was 99.3 percent. However, 12.4 percent of the dental implants required additional interventions, compared with 1.4 percent of the root canals. “Considering these results in

Alcohol Containing Mouth Rinse linked with Increased Cancer Risk

Australian researchers have linked mouthwash containing alcohol to an increased risk of developing oral cancer. The alcohol in mouthwash is believed to allow cancer causing compounds to attack the lining of the mouth more easily. The review author, Michael McCullough, is an Associate Professor in Oral medicine at Melbourne University. He says dentists need to be aware of the risks of mouthwash. “If they are going to recommend alcohol-containing products then they recommend it for a good reason, for a

Nanocrystallizing Implant Surfaces Reduces Biofilm Infections

Canadian researchers at the University of Alberta have found the surface nanocrystallization of a metallic material is an effective approach for modifying the surface energy of metals. “Our results demonstrate that the combination of surface nanocrystallization and thermal oxidation treatment is a promising approach to suppress the formation of infectious biofilms on metallic materials, thus providing a surface technique to minimize bacterial biofilms on implant surfaces for improved orthodontic and orthopedic applications” says Li the lead researcher. This surface modification

Histatin Speeds Oral Healing

A report by scientists from the Netherlands published in the FASEB Journal identifies a compound in human saliva that greatly speeds wound healing. Scientists found that Histatin, a small protein in saliva previously only believed to kill bacteria was responsible for the healing. Because saliva is a complex liquid with many components, the next step was to identify which component was responsible for wound healing. Using various techniques the researchers split the saliva into its individual components, tested each in

Nanocrystalline Titanium shows Exceptional Mechanical Properties

Novel processing of commercially pure titanium (CP Ti) has produced exceptional mechanical properties and recent clinical trials have proven its superior biocompatibility as well. CP Ti is desirable mainly for its superior biocompatibility, but suffers from low strength compared to either steel or alloyed titaniums. Severe plastic deformation (SPD) processing aims to get microstructural refinement to a level not achievable with traditional processing yielding nanocrystalline titanium. Fatigue life has nearly doubled and although damage tolerance suffered, the levels are still

Nanoparticles Aid Bone Growth

Bioengineers and bioscientists at Rice University and Radboud University in Nijmegen, Netherlands, have shown they can grow denser bone tissue by sprinkling stick-like nanoparticles throughout the porous material used to pattern the bone. To grow new bone, tissue engineers typically place bone cells on porous, biodegradable materials called scaffolds, which act as patterns. With the right chemical and physical cues, the cells can be coaxed into producing new bone. As the scaffold degrades, it is replaced by new bone. “Ideally,

Cannabis Smoking may be a Risk factor for Periodontal Disease – Peri-Implantitis?

Researchers at the Dunedin School of Medicine, Dunedin, New Zealand have reported in the Journal of the American Medical Association (JAMA) that Cannabis smoking may be a risk factor for periodontal disease that is independent of the use of tobacco. Tobacco smoking was strongly associated with periodontal disease experience, but there was no interaction between cannabis use and tobacco smoking in predicting the condition`s occurrence

Osteo Odonto Kerato Prosthesis

Dr Christopher Lie of the Sussex Eye Hospital in Brighton, England performed a sight restoring procedure called Osteo Odonto Kerato Prosthesis (OOKP) which involves fitting a living canine tooth with an optical cylinder and transplanting it into the eye cavity, restoring a blind Irishman`s sight. The procedure involves removing a canine tooth, a part of the adjacent bone and related ligaments from a patient. It is attached in the first stage to the cheek area to develop a blood supply

Dark-Field Xray Imaging Improves Diagnostic Resolution

Swiss Researchers at the Paul Scherrer Institute have developed a novel method for producing dark-field x-ray images at wavelengths used in typical medical and industrial imaging equipment. Dark-field images provide more detail than ordinary x-ray radiographs and could be used to diagnose the onset of osteoporosis, breast cancer or Alzheimer’s disease. Unlike traditional x-ray images, which show a simple absorption contrast, dark-field images capture the scattering of the radiation within the material itself, exposing subtle inner changes in bone, soft

Maxillary Bone Regeneration using Stem Cells

Researchers at the Regea Institute of Regenerative Medicine, part of the University of Tampere, Finland have successfully replaced a 65-year-old patient`s upper jaw with a bone transplant cultivated from stem cells isolated from his own fatty tissue and grown inside his abdomen. Stem cells were isolated from the patient`s fat and grew for two weeks in a specially formulated nutritious soup that included the patient`s own blood serum. When they had enough cells to work with, they attached them to

Saliva Test for Breast Cancer

Researchers at The University of Texas Health Science Center at Houston can identify and quantify specific protein markers in human saliva to provide an early, non-invasive diagnosis of breast cancer, according to a study published in today’s issue of the journal Cancer Investigation. “Why not the dentist?” said lead researcher Charles Streckfus, D.D.S., . “Most folks, especially women and children, visit the dental office way more often than they ever see the physician. Saliva is a non-invasive, quicker way for

Gold Nanoparticles Laser Sintered to Reduce Dentinal Hypersensitivity

Researchers at the Chemistry and Biochemistry Department at National Chung Cheng University in Taiwan has published a paper in Nanotechnology demonstrating the use of gold nanoparticles in occluding dental tubules. Researchers have found that sensitive teeth have an increased number of dentinal tubules (35.6% compared to 9.3%) and are wider in diameter (0.83 µm compared to 0.43 µm) than the dentinal tubules of non sensitive dentine. The Chinese researchers have demonstrated that this tubules can be blocked with the aid

Oral Bisphosphonate-Induced Osteonecrosis Clinical Management Paper Published

Drs. Marx et al. of the University of Miami have published a comprehensive paper on `Risk factors, Prediction of Risk using Serum CTX Testing, Prevention and Treatment` of Oral Bisphosphonate-Induced Osteonecrosis in the December 2007 issue of the Journal of Oral Maxillofacial Surgery (pages 2397-2410). It gives specific guidelines to help to assess the risk of BRONJ and a suggested course of treatment should the condition develop in one of your patients.

Increase in CT Scan use increases Cancer Risk

A New England Journal of Medicine article found that the number of CT Scans most people are exposed to had risen dramatically in the past 27 years. In 1980, doctors ordered an average of 3 million scans per year in the United States. Now, about 62 million CT Scans are done each year in this country. The rise in CT Scans can be attributed, in part, to an increase in `defensive` medicine. This occurs, for example, when people who are

Carbon Nanotubes Double Human Osteoblast Growth Rate

A team of Brown University engineers, led by Thomas Webster, has discovered a new material that could significantly increase osseointegration success rate. Osteoblasts grow faster and produce more calcium on anodized titanium covered in carbon nanotubes compared with plain anodized titanium and the non-anodized version currently used in orthopaedic implants. The work, published in Nanotechnology, uncovers a new material that can be used to make more successful implants. The research also shows tantalizing promise for an all-new device: a “smart”

Harvard Researchers Pioneer Pain-Specific Local Anesthesia from Chili Peppers

The new method exploits a membrane-spanning protein called TRPV1, which is unique to pain-sensing neurons. TRPV1 forms a large channel, where molecules can enter and exit the cell. But a “gate” typically blocks this opening. The gate opens when cells are exposed to heat or the chili-pepper ingredient capsaicin. Thus, bathing pain-sensing neurons in capsaicin leaves these channels open, but non-pain sensing neurons are unaffected because they do not possess TRPV1. “We’re optimistic that this method will eventually be applied

MIT Investigates Molecular Mechanism Responsible for Bone`s Toughness

Professor Markus Buehler of MIT`s Department of Civil and Environmental Engineering has revealed for the first time the role of bone`s atomistic structure in a toughening mechanism that incorporates two theories previously proposed by researchers eager to understand the secret behind the material`s lightweight strength. He studied the molecular structure of the mineralized collagen fibrils that make up level 2 bone, hoping to find the mechanism behind bone`s strength, which is considerable for such a lightweight, porous material. When pressure

Dento-Munch – A Robotic Chewing System

UK Researchers have developed a robotic system that mimics human biting and chewing. The `Dento-Munch` system will be used to test dental materials for wear and tear. It is seen as a less expensive and less time-consuming alternative to clinical trials. The robot that can reproduce the full movement of the human jaw. Two platforms act as the upper and lower jaws, with the lower jaw capable of moving in 6 degrees of freedom. Just like the human jaw, it

Self-Regeneration of Teeth with the Wnt Pathway

Researchers from the Institute of Biotechnology at the University of Helsinki and their collaborators from Berlin and Kyoto have now shown that continuous tooth generation can be induced in mammals. The research results were published in `Proceedings of the National Academy of Sciences,` (PNAS). The researchers activated the Wnt signaling pathway in mouse tissue; this signaling pathway is one of those used for cell communication and plays an important role in embryonic development. As a result of stimulating this particular

Stem Cells used to Regenerate Dentin and PDL in a HA Implant

Using stem cells harvested from the extracted wisdom teeth of young adults, researchers have successfully generated tooth root and supporting tooth ligaments to support a crown restoration in experiments using miniature pigs. The restored tooth mirrored the original tooth in function and strength, the research team reports in the December issue of the open access medical journal PLoS ONE. The technique holds promise for use in humans, the investigators say. Dr. Songtao Shi said: “In this study, we use stem