Intelligent Metal Surfaces direct Osteoblast Cell Activity and Fate

Université de Montréal Researchers have modified metal surfaces such as titanium producing a sponge-like pattern of nano pits that increased growth of bone cells, decreased growth of unwanted cells and stimulated stem cells, relative to untreated smooth ones. In addition, expression of genes required for cell adhesion and growth were increased in contact with the nanoporous surfaces. “We demonstrated that some cells stick better to these surfaces than they do to the traditional smooth ones,” says Dr. Nanci. “This is already an improvement to the standard available biomaterial.” “Using chemical modification, we have produced metals with intelligent surfaces that positively interact with cells and help control the biological healing response. These will be the building-blocks of new and improved metal implants that are expected to significantly affect the success of orthopedic, dental and cardiovascular prostheses.”

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